Immunopathogenesis of Libman-Sacks endocarditis. Assessment by light and immunofluorescent microscopy in two patients.
نویسندگان
چکیده
منابع مشابه
Libman-Sacks Endocarditis
In 1924 Libman and Sacks published an account of atypical, sterile, verrucous vegetations on the heart in systemic lupus erythematosus (SLE). [1] Clusters of verrucae, looking like mulberries, were described on the ventricular surface of the posterior leaflet of the mitral valve and found at postmortem. The leaflet and the chordae tendinae are often adherent to the endocardium of the ventricula...
متن کاملLibman-Sacks endocarditis and oral anticoagulation.
The patient is a 34-year-old female with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome, who evolved with convulsive crises, partially controlled with an anticonvulsant, and auscultation of a cardiac murmur, whose investigation showed the presence of a mitral valve vegetation. Once the diagnosis of Libman-Sacks endocarditis was established, therapy with warfarin s...
متن کاملAortic valve replacement for Libman-Sacks endocarditis
A 24-year-old man with systemic lupus erythematosus and antiphospholipid syndrome complicated by lupus nephritis presented with acute limb ischaemia secondary to an embolus. Following embolectomy, the patient underwent a transthoracic echocardiogram which revealed a large vegetation on all three cusps of the aortic valve. The patient was taken for an urgent aortic valve replacement with a mecha...
متن کاملLupus-Negative Libman-Sacks Endocarditis Complicated by Catastrophic Antiphospholipid Syndrome
Libman-Sacks endocarditis is characterized by sterile and verrucous lesions that predominantly affect the aortic and mitral valves. In most cases, patients do not have significant valvular dysfunction. However, patients with significant valvular dysfunction may present with serious complications such as cardiac failure, arrhythmias, and thromboembolic events. Recently, association of Libman-Sac...
متن کامل[Severe mitral regurgitation in Libman-Sacks endocarditis. Conservative surgery].
Libman-Sacks endocarditis is a classic but rarely symptomatic manifestation of systemic lupus erythematosus, and valvular surgery is needed in a few cases. We present a patient with systemic lupus erythematosus and Libman-Sacks endocarditis that progressed rapidly to severe mitral regurgitation that needed surgery; surgical valve repair was decided upon. The literature on this topic is reviewed.
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1977
ISSN: 0003-4967
DOI: 10.1136/ard.36.6.508